Award
National Heart, Lung, and Blood Institute 5R01HL151685-05
Molecular Imaging CCR2 Lung Inflammation and Fibrosis
Recipient
Washington University, Saint Louis, MO, United States
Award Amount
$710,780.00
Ceiling
$710,780.00
Awarded
January 03, 2025
Identifier
5R01HL151685-05
NIH grant awarded to Washington University for developing PET imaging techniques to detect and monitor CCR2+ cells in pulmonary fibrosis, aiming to improve diagnosis and treatment of IPF.
Description
This project addresses the challenge of caring for patients with idiopathic pulmonary fibrosis (IPF), a lung disease with short survival and limited therapeutic options. The research involves developing a radiotracer for PET scans to image CCR2+ monocytes, which are pathogenic in pulmonary fibrosis. Studies will use mouse models to assess therapies targeting CCR2 cells and monitor responses via CCR2-PET imaging, with the goal of translating findings to human disease management.