Award
NIH Reporter #1R01AI198632-01
The NOX-ATM pathway regulates host microbe interactions, cytokine production and gut epithelial dynamics
Recipient
Cornell University, Ithaca, NY, United States
Award Amount
$2,607,562.00
Ceiling
$2,607,562.00
Awarded
July 08, 2026
Identifier
1R01AI198632-01
Research project funded by NIAID to study the NOX-ATM pathway's role in immune response and tissue repair during microbial infection using Drosophila melanogaster as a model.
Description
This project proposes to study a new immune/stress pathway (NOX-ATM-Cytokine), that responds to bacterial virulence and shapes innate immunity and tissue repair. The project hypothesizes that ATM-mediated signaling is a central stress response upon infection, modulating cytokine production, cell death, and survival.