Award
NIH Reporter #5R01GM143182-04
Physicochemical properties driving membraneless organelle assembly in bacteria
Recipient
University of Michigan at Ann Arbor, MI
Award Amount
$523,010.00
Ceiling
$523,010.00
Awarded
August 09, 2024
Identifier
5R01GM143182-04
A multidisciplinary research project investigating phase-separated membraneless organelles in bacteria, particularly focusing on the Dps protein's role in chromosome organization and bacterial survival, using experimental and computational methods.
Description
This project explores the structural organization of the bacterial cytoplasm and characterizes phase-separated membraneless organelles in bacteria, focusing on the DNA-binding protein from starved cells (Dps). The research combines in vitro, in vivo, and in silico approaches to understand the chemical and mechanical properties of these organelles, their formation, and their role in bacterial chromosome organization and survival.