NIH Reporter #5R01NS128006-04

Clinical Stimulation and Spreading Depolarization

This award funds research to investigate if routine clinical interventions in ICU patients with severe strokes trigger spreading depolarization events that worsen stroke outcomes, using advanced monitoring techniques to inform potential therapeutic strategies.

Description

The study aims to determine whether normal interventions in the intensive care unit are associated with an increased risk of spreading depolarization (SD) in the sensorimotor cortex in patients with large hemispheric strokes. The research involves using subdural electrocorticography electrodes paired with tissue oxygen probes and long-term video EEG recordings to assess stimulation events and physiological measurements time-locked with SD recordings. The goal is to understand mechanisms, consequences, and therapeutic approaches related to SD in acute neurological injury, which could impact stroke outcomes and inform future therapeutic efforts.

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