Award
National Institute of Allergy and Infectious Diseases 1R15AI174169-01A1
Effects and mechanisms of cold-induced stress on the development of Chlamydia muridarum genital infection in a mouse model
Recipient
Tesfaye Belay
Award Amount
$444,000.00
Ceiling
$444,000.00
Awarded
July 14, 2023
Identifier
1R15AI174169-01A1
This award funds research on the effects of cold-induced stress on Chlamydia muridarum genital infection in mice, focusing on the role of norepinephrine and beta2-adrenergic receptor pathways in immune response and disease severity.
Description
The project investigates how cold water-induced norepinephrine secretion influences infection intensity, immune cell functions, and pathology in a mouse model of Chlamydia muridarum genital infection. It uses stress-hormone-receptor-deficient mice to test infection minimization compared to controls, aiming to isolate mechanisms through which stress worsens chlamydia disease.