Award
National Institute of Neurological Disorders and Stroke 5R01NS119166-06
Astrocytic WNK-SPAK-NKCC1 Cascade in White Matter Astrogliosis and Injury
Recipient
Louisiana State University Health Sciences Center Shreveport
Award Amount
$450,735.00
Ceiling
$450,735.00
Awarded
March 27, 2026
Identifier
5R01NS119166-06
Research project funded to study molecular mechanisms of brain lesions and cognitive deficits related to VCID, focusing on astrocytic signaling and therapeutic interventions.
Description
This project investigates the activation of the WNK-SPAK-NKCC1 protein complex in white matter and hippocampus using mouse models of VCID with chronic bilateral carotid artery stenosis (BCAS). The study aims to elucidate molecular mechanisms underlying brain lesions and cognitive deficits, focusing on astrocytic signaling pathways and potential therapeutic interventions with SPAK inhibitors.