Award
National Institute of Allergy and Infectious Diseases 1R21AI185660-01A1
Reversing Graft Rejection by Targeting Innate Immune Memory with Novel Nanobiologics
Recipient
University of Pittsburgh at Pittsburgh, Pittsburgh, PA, United States
Award Amount
$452,835.00
Ceiling
$452,835.00
Awarded
January 29, 2026
Identifier
1R21AI185660-01A1
This NIH grant funds research on developing nanotherapeutics to inhibit immune cells involved in transplant rejection by targeting innate immune memory mechanisms, aiming to improve long-term transplant outcomes.
Description
A project to investigate the role of Hsp70i in innate immune memory responses and T cell mediated rejection (TCMR), and to evaluate nanobiologic targeting of mTOR and Hsp70i pathways to inhibit immune responses and improve long-term allograft outcomes.