Award
National Institute of General Medical Sciences 1R35GM162577-01
Dissecting the control of transcription elongation
Recipient
Harvard Medical School
Award Amount
$165,279.00
Ceiling
$165,279.00
Awarded
June 30, 2026
Identifier
1R35GM162577-01
This award funds research at Harvard Medical School to study the mechanisms controlling transcription elongation by RNA polymerase II and its coordination with RNA processing, with implications for understanding diseases caused by dysregulation of these processes.
Description
The project aims to probe the mechanisms allowing coordination between RNA polymerase II elongation and RNA processing to improve understanding of disease states where these processes are dysregulated. It involves studying the control of gene expression, transcription elongation, and RNA processing, focusing on the role of the Integrator complex and other factors in regulating RNA polymerase II activity and mRNA synthesis.