Award
National Institute of General Medical Sciences 1R35GM161838-01
Elucidating the Molecular Determinants of Functional Specificity in Intrinsically Disordered Proteins
Recipient
University of North Carolina at Chapel Hill
Award Amount
$413,946.00
Ceiling
$413,946.00
Awarded
April 01, 2026
Identifier
1R35GM161838-01
NIH grant awarded to University of North Carolina at Chapel Hill to study molecular determinants of functional specificity in intrinsically disordered proteins, focusing on protein interactions and functional specificity mechanisms.
Description
This project aims to develop models to understand intrinsically disordered proteins (IDPs) functions by studying their molecular interactions with cellular partners, focusing on the CITED family of transcriptional regulators. The research seeks to elucidate how IDPs achieve functional specificity through multivalent interactions and conformational dynamics.