Award
National Institute of Allergy and Infectious Diseases 1K99AI185158-01A1
Exploring mechanisms of activation of an innate immune pathway by fungal extracellular vesicles
Recipient
Massachusetts General Hospital
Award Amount
$197,240.00
Ceiling
$197,240.00
Awarded
September 03, 2025
Identifier
1K99AI185158-01A1
NIH grant awarded to Massachusetts General Hospital to study how fungal extracellular vesicles activate innate immune pathways, focusing on the cGAS-STING pathway and its role in fungal infections.
Description
This NIH grant project aims to identify the mechanism by which a human fungal pathogen, such as Candida albicans, activates the cGAS-STING pathway through fungal extracellular vesicles, leading to a lethal inflammatory response that clears the fungal infection. The project includes training in EV isolation, bioinformatics, and animal models, and seeks to elucidate the role of fungal EVs in immune activation.