Award
National Institute of Allergy and Infectious Diseases 5R01AI106872-10
Mechanisms and Consequences of Mycobacterial N-terminal Protein Acetylation
Recipient
University of Notre Dame
Award Amount
$469,500.00
Ceiling
$469,500.00
Awarded
July 19, 2024
Identifier
5R01AI106872-10
NIH awarded $469,500 to University of Notre Dame for research on N-terminal protein acetylation in mycobacteria, focusing on its mechanisms and impact on virulence, potentially aiding tuberculosis treatment development.
Description
This project aims to define the mechanisms underlying N-terminal acetylation in mycobacteria, hypothesizing that it is a dynamic, regulated process impacting virulence. The research involves biochemical, genetic, and proteomic approaches to identify enzymes promoting Nt-acetylation, establish mechanisms and consequences of virulence factor Nt-acetylation, and determine the link between Nt-acetylation and mycobacterial metabolism. The project may lead to new therapeutic targets for tuberculosis.