Award
NIH Reporter #5F31DK139666-03
Targeting cDC1 with CAR T cells to investigate their role and potential as a therapeutic target in Type 1 diabetes
Recipient
Washington University
Award Amount
$35,763.00
Ceiling
$35,763.00
Awarded
August 05, 2026
Identifier
5F31DK139666-03
This award funds research to develop CAR T cell therapy targeting cDC1 cells to prevent Type 1 diabetes by depleting these cells and evaluating therapeutic efficacy in a mouse model.
Description
The project aims to develop a chimeric antigen receptor (CAR) T cell therapy targeting XCR1, a receptor on cDC1 cells, to prevent Type 1 diabetes by depleting these cells. The study will validate the specificity of the CAR, assess the durability of cDC1 depletion, and evaluate the impact on autoimmune diabetes in NOD mice.