National Institute of Diabetes and Digestive and Kidney Diseases 5F31DK139621-02

Circadian Clock Regulation of HIF1a-dependent Skeletal Muscle Metabolism during Diet-induced Obesity

This award supports research on how the skeletal muscle molecular clock regulates metabolism and muscle mass during diet-induced obesity, focusing on the HIF pathway interaction to improve understanding and treatment of metabolic diseases.

Description

The project focuses on the regulation of skeletal muscle metabolism by the circadian clock during diet-induced obesity. The research aims to elucidate the interaction between the molecular clock and hypoxia-inducible factor (HIF) pathway. It involves studying the role of the skeletal muscle molecular clock and HIF1α in glucose metabolism and muscle mass maintenance. The project is conducted under the study section "Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]" and aims to provide insights into clock control of skeletal muscle metabolism during nutrient stress, aligned with understanding metabolic syndrome and developing better therapies.

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