Award
National Institute of General Medical Sciences 3R01GM143400-04S1
Single-component optogenetic tools to bidirectionally control RhoA in mechanotransduction
Recipient
University of Pennsylvania
Award Amount
$91,704.00
Ceiling
$91,704.00
Awarded
August 26, 2025
Identifier
3R01GM143400-04S1
The award funds the development of optogenetic tools to control RhoA signaling, enhancing understanding of cell mechanics and signaling pathways.
Description
This project aims to engineer, benchmark, and demonstrate the unique capabilities of an optogenetic toolbox to bi-directionally (activation and inactivation) control RhoA signaling to advance fundamental understanding of cell contractility, motility, and mechanotransduction.