Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 1R01AR083994-01A1
Investigating the role of A20 and DREAM in adipogenesis and systemic sclerosis
Recipient
University of Michigan at Ann Arbor
Award Amount
$637,567.00
Ceiling
$637,567.00
Awarded
September 17, 2025
Identifier
1R01AR083994-01A1
Research project studying the role of A20 and DREAM in adipogenesis and fibrosis in systemic sclerosis, aiming to develop therapeutic strategies by modulating A20 expression.
Description
The project investigates mechanisms of how A20 promotes adipogenesis and the effects of low A20 levels in scleroderma (SSc) patients, focusing on transdifferentiation of adipocytes to mesenchymal phenotype and fibrosis initiation. It explores whether blocking DREAM can restore A20 activity and reduce fibrosis.