Award
NIH Reporter #1R21AI202189-01
Bacteriophage interactions with nontuberculous mycobacteria in the intracellular environment of mammalian cells
Recipient
Colorado State University, Fort Collins, CO
Award Amount
$423,500.00
Ceiling
$423,500.00
Awarded
August 18, 2026
Identifier
1R21AI202189-01
Research project funded by NIAID to study bacteriophage activity within mammalian cells to improve phage therapy against intracellular infections caused by nontuberculous mycobacteria.
Description
This project investigates the biological interactions and mechanisms that promote or prevent bacteriophages from functioning within mammalian cells, aiming to improve phage therapy for intracellular bacterial infections such as those caused by nontuberculous mycobacteria (NTM). The research focuses on understanding phage entry, trafficking, and activity in mammalian cells, and how these processes can be optimized to treat drug-resistant bacteria like Mycobacterium abscessus.