Award
National Institute of Allergy and Infectious Diseases 5R01AI182977-02
Tissue specific immunity to fungal infections
Recipient
Hackensack University Medical Center
Award Amount
$883,729.00
Ceiling
$883,729.00
Awarded
November 26, 2025
Identifier
5R01AI182977-02
NIH grant awarded to study the role of Gcn5 in fungal virulence and immune response to Candida albicans infections, aiming to develop novel therapeutic strategies.
Description
This research aims to understand how Candida albicans adapts to different host niches, focusing on the role of Gcn5 lysine acetyl transferase in regulating cellular proteins during infection. The study will identify in vivo targets of Gcn5 in murine models of oropharyngeal and invasive candidiasis, and how these interactions influence immune responses and virulence.