Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK141090-02
Metabolic Actions of Glucagon
Recipient
Duke University, Durham, NC
Award Amount
$793,072.00
Ceiling
$793,072.00
Awarded
July 14, 2026
Identifier
5R01DK141090-02
NIH grant awarded to Duke University to study glucagon's role in glucose regulation and metabolism, with implications for diabetes and related diseases.
Description
This project aims to elucidate the complex roles of glucagon in blood glucose regulation and metabolism. It explores how hepatic glucagon receptors engage divergent signaling pathways, including G-protein and β-arrestin pathways, to differentially regulate glucose production and insulin sensitivity. The research involves physiological and pharmacological studies in novel mouse models and parallel experiments in human subjects to validate translational potential. The findings could significantly impact therapies for diabetes, obesity, and liver disease.