Award
National Institute of Allergy and Infectious Diseases 5R01AI114720-08
Identification of the untranslated sequence elements and virus-host interactions that modulate flavivirus host-specificity
Recipient
Iowa State University
Award Amount
$374,132.00
Ceiling
$374,132.00
Awarded
April 17, 2026
Identifier
5R01AI114720-08
Research project funded by NIAID to study genetic and virus-host interaction factors affecting flavivirus host-specificity, focusing on untranslated regions and viral proteins.
Description
The project aims to identify the genetic determinants and virus-host interactions that modulate the differential host ranges of mosquito-borne flaviviruses (MBFVs) and dual-host affiliated insect-specific flaviviruses (dISFs), focusing on untranslated regions, NS3 helicase, and NS5 RNA polymerase. The research involves dissecting viral genomes, identifying host proteins that bind to viral RNA and proteins, and characterizing these interactions to understand host-specificity.