National Heart, Lung, and Blood Institute 11375490

Metabolic Reprogramming in Experimental Deep Vein Thrombosis and Resolution

This award funds research on metabolic reprogramming to treat deep vein thrombosis, focusing on mechanisms to limit inflammation and promote thrombus resolution using human samples and animal models.

Description

The project focuses on exploring metabolic reprogramming as an approach to treat deep vein thrombosis and related conditions. The research involves human samples and cell-specific mutant mice. The project aims to define mechanisms that limit chronic inflammation and promote thrombus resolution. The funding is provided by the National Heart Lung and Blood Institute (NHLBI), part of NIH. The project includes aims to define the role of PKM2 in DVT progression and resolution. The research will utilize the femoral vein thrombosis model in mice and rats. The project emphasizes novel strategies to improve vascular integrity and motor function. The project is part of the PA-20-185 funding opportunity.

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