Award
NIH Reporter #5R21CA296062-02
Sequential infection of laboratory mice for enhanced cancer and immunotherapy translation
Recipient
UNIVERSITY HEALTH NETWORK
Award Amount
$138,848.00
Ceiling
$138,848.00
Awarded
June 19, 2026
Identifier
5R21CA296062-02
The award supports research to create a mouse model with an adult-like immune system to better replicate human responses to cancer and immunotherapy, enhancing translational research.
Description
This project aims to develop a lab-generated “wild-like” mouse model that mimics the adult human immune system to improve the translation of cancer and immunotherapy research from bench to bedside. The model addresses the limitations of standard mouse models that lack exposure to infections and vaccinations, which are critical for immune maturation.