Award
NIH Reporter #1R01EY038335-01A1
The role of the CNG channel-NCKX exchanger complex in maintaining photoreceptor outer segment integrity
Recipient
Duke University
Award Amount
$629,520.00
Ceiling
$629,520.00
Awarded
August 21, 2026
Identifier
1R01EY038335-01A1
Research project funded by the National Eye Institute to study the role of the CNG channel-NCKX exchanger complex in maintaining the structural and functional integrity of photoreceptor outer segments, with potential implications for inherited blindness.
Description
This project aims to elucidate the molecular mechanisms supporting the structural and functional integrity of photoreceptor outer segments, with implications for understanding inherited blindness. The experiments address how photoreceptor cells build and maintain their light-sensitive outer segment organelles, focusing on the CNG channel/NCKX exchanger complex's role in sustaining outer segment structural integrity.