Award
National Institute of General Medical Sciences 1R35GM162272-01
Tracing developmental signaling histories with imaging-based molecular recording
Recipient
University of California Los Angeles
Award Amount
$433,125.00
Ceiling
$433,125.00
Awarded
March 23, 2026
Identifier
1R35GM162272-01
Development of a molecular recording system to track cell signaling histories using CRISPR base editors, facilitating long-term analysis of cell fate and tissue organization in mammalian systems.
Description
This project develops a heritable molecular recording system using CRISPR base editors to track signaling activity in single cells over time, enabling long-term analysis of cell signaling histories and their impact on cell fate and tissue organization.