Award
NIH Reporter #5F31NS139645-02
Investigating the Molecular and Cellular Basis of RNA Exosome-linked Pontocerebellar Hypoplasia Type1b in Human 3D Brain Organoids
Recipient
National Institute of Neurological Disorders and Stroke (NINDS), part of the NIH
Award Amount
$46,168.00
Ceiling
$46,168.00
Awarded
August 04, 2026
Identifier
5F31NS139645-02
Award for research investigating the molecular and cellular basis of RNA exosome-linked Pontocerebellar Hypoplasia Type1b using human 3D brain organoids, focusing on cell fate determination and disease mechanisms.
Description
This project aims to elucidate the role of the RNA exosome in cell fate determination within the cerebellum and establish whether defective differentiation is a critical component of PCH1b pathogenesis. It involves generating human induced pluripotent stem cells with disease-causing mutations, analyzing gene expression, and performing functional assays on cerebellar organoids.