Award
National Heart, Lung, and Blood Institute 1F31HL179994-01
The role of sex chromosomes in neonatal hyperoxic lung injury
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$49,538.00
Ceiling
$49,538.00
Awarded
July 18, 2025
Identifier
1F31HL179994-01
The award funds research on how sex chromosomes influence neonatal lung injury caused by high oxygen levels, focusing on genetic and epigenetic mechanisms that may explain sex differences in disease severity and incidence.
Description
This project investigates the role of sex chromosome dosage and the X-linked gene Kdm6a in neonatal hyperoxic lung injury using mouse models. The goal is to understand sex-specific responses to lung injury, particularly the protective effect of the female XX chromosome complement, to inform precision medicine approaches for bronchopulmonary dysplasia (BPD) in preterm neonates.