Award
National Institute of Allergy and Infectious Diseases 1R21AI187788-01A1
CD27-mediated immune suppression by HSPCs, innate immune cells or non-hematopoietic cells
Recipient
University of Maryland Baltimore, Baltimore, MD, United States
Award Amount
$427,625.00
Ceiling
$427,625.00
Awarded
July 23, 2025
Identifier
1R21AI187788-01A1
The award supports research on the CD27-CD70 pathway in hematopoietic stem and progenitor cells to understand their immune regulatory functions and improve therapeutic applications in immunological disorders and stem cell transplantation.
Description
This project investigates the immune regulatory functions of hematopoietic stem and progenitor cells (HSPCs) via the CD27-CD70 pathway, with implications for improving stem cell transplantation outcomes and treating immunological disorders. The study explores the role of CD27 in HSPCs in modulating immune responses and graft-versus-host disease (GVHD).