Award
National Institute of Neurological Disorders and Stroke 5R01NS122165-05
Uncover the role of H3.3-G343R mutation in shaping the DNA damage response, anti-tumor immunity and mechanisms of resistance in glioma.
Recipient
University of Michigan at Ann Arbor, Department of Neurosurgery, MI, USA
Award Amount
$505,859.00
Ceiling
$505,859.00
Awarded
February 20, 2026
Identifier
5R01NS122165-05
A research project funded by NINDS to investigate the role of H3.3-G34R mutation in pediatric high-grade gliomas, focusing on DNA damage response, immune activation, and resistance mechanisms to identify targeted therapies.
Description
This project aims to study a subtype of pediatric high-grade gliomas harboring H3.3-G34R, ATRX, and TP53 mutations, focusing on molecular mechanisms affecting tumor biology, immune microenvironment, and therapeutic response using genetically engineered mouse models.