Award
National Heart, Lung, and Blood Institute 5F31HL176101-02
The Role of c-ABL in Mediating TIE2 Signaling and Formation of Venous Malformation
Recipient
University of Cincinnati, Cincinnati, OH, United States
Award Amount
$46,950.00
Ceiling
$46,950.00
Awarded
August 14, 2025
Identifier
5F31HL176101-02
Research project investigating the role of c-ABL in TIE2 signaling and venous malformation formation using a novel mouse model, aiming to understand disease mechanisms and explore therapeutic targets.
Description
This project aims to define the effects of c-ABL on TIE2 activation and signaling and to determine if c-ABL is required for venous malformation lesion formation in vivo, utilizing in vitro functional assays and a transgenic mouse model. It will establish a genetic mouse model of mutant TIE2-driven venous malformation, essential for further mechanistic studies and therapeutic testing.