Award
National Institute on Aging 1R21AG083593-01
Investigate the utility of APLP1 as an endosomal biomarker for Alzheimer's Disease in Down Syndrome
Recipient
Columbia University Health Sciences, New York, NY, United States
Award Amount
$452,375.00
Ceiling
$452,375.00
Awarded
August 15, 2023
Identifier
1R21AG083593-01
A research project funded by the National Institute on Aging to develop biomarkers for early detection of Alzheimer's Disease in Down Syndrome using proteomic analysis and human sample validation.
Description
This project aims to develop and validate biomarkers of endosomal dysfunction, focusing on the protein fragment n-APLP1, as an early indicator of Alzheimer's Disease progression in individuals with Down Syndrome. The study involves proteomic analysis in mouse models and validation in human CSF samples.