Award
National Institute on Aging 5R01AG071567-05
Microvascular Stress as a Pathway to Neurodegeneration in Alzheimer's
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$418,276.00
Ceiling
$418,276.00
Awarded
February 09, 2026
Identifier
5R01AG071567-05
Research project investigating microvascular stress as a key factor in Alzheimer's disease progression, using human and mouse models to identify mechanisms and potential therapeutic targets.
Description
This project aims to elucidate the role of microvascular stress in Alzheimer’s disease, utilizing advanced imaging, molecular, and genetic techniques to identify potential therapeutic targets and biomarkers. The research will use human tissue samples and mouse models to examine microvascular stress contribution to Alzheimer's disease, focusing on inflammation, senescence, angiogenesis, and blood brain barrier function.