Award
National Institute of Neurological Disorders and Stroke 5R01NS119804-05
Aryl hydrocarbon receptor and bilirubin as therapeutic target for ICH
Recipient
University of Texas Health Science Center Houston
Award Amount
$471,323.00
Ceiling
$471,323.00
Awarded
May 29, 2025
Identifier
5R01NS119804-05
This award funds a research project at the University of Texas Health Science Center Houston to study the therapeutic potential of targeting the aryl hydrocarbon receptor and bilirubin pathways in microglia/macrophages for improving outcomes after intracerebral hemorrhage.
Description
Research project investigating the role of aryl hydrocarbon receptor and bilirubin in microglia/macrophages for therapeutic targeting in intracerebral hemorrhage (ICH). The study focuses on mechanisms of hematoma clearance, cell survival, and neurological recovery using mouse models and potential therapeutic agents such as AhR agonist ITE and Nrf2 activator sulforaphane.