Award
NIH Reporter #5U24CA264006-05
A Genome Data Analysis Center Focused on Batch Effect Analysis and Data Integration
Recipient
University of TX MD Anderson Cancer Center, Houston, TX, United States
Award Amount
$403,310.00
Ceiling
$403,310.00
Awarded
August 12, 2025
Identifier
5U24CA264006-05
This award funds the development and enhancement of the Genome Data Analysis Center to address batch effects in cancer genomics data, improve data integration and visualization, and support cancer research through advanced bioinformatics tools and collaboration.
Description
The Genome Data Analysis Center (GDAC) project aims to perform batch effects identification, quantitation, diagnosis, and correction; contribute to integrated cluster analysis, RPPA proteomic data analysis, and high-level visualization of omic data including single-cell sequencing; and communicate results to network members, stakeholders, and the scientific community. The GDAC supports projects managed by the Center for Cancer Genomics (CCG) to better understand cancer biology and resistance mechanisms. The project involves developing and extending the MBatch software system for quality control and correction of batch effects, collaborating with other centers, providing integrated clustering solutions, high-level visualization tools, and analyzing RPPA proteomic data. The team has expertise in bioinformatics, biostatistics, cancer biology, and software engineering, with significant computational resources.