Award
NIH Reporter #5R35GM131687-08
Novel regulatory networks driving human ribosome biogenesis
Recipient
Yale University, New Haven, CT, United States
Award Amount
$686,911.00
Ceiling
$686,911.00
Awarded
April 08, 2026
Identifier
5R35GM131687-08
Research project funded by the National Institute of General Medical Sciences to study human ribosome biogenesis and its role in diseases such as cancer, using genome-wide screening and model systems.
Description
This project aims to elucidate the mechanisms of ribosome biogenesis in human cells and its connection to human diseases, including cancer and genetic disorders. The research involves a genome-wide siRNA screen in human breast epithelial cells to identify proteins involved in nucleolar function and ribosome production. The study will extend to non-coding RNAs, microRNAs, and model systems like Xenopus tropicalis to understand regulatory pathways and disease implications.