Award
NIH Reporter #5R01MH124811-05
CaV2.2 splice variants in the hippocampus: function and pharmacology
Recipient
Brown University
Award Amount
$385,208.00
Ceiling
$385,208.00
Awarded
April 27, 2026
Identifier
5R01MH124811-05
Research grant awarded to study the function and pharmacology of CaV2.2 splice variants in the hippocampus, focusing on cannabinoid effects and neuronal communication.
Description
This project aims to elucidate the basic mechanisms of neuronal communication and the effects of cannabinoids on neuronal communication, focusing on the regulation and function of CaV2.2 channels in the hippocampus. The study will investigate how alternative splicing of exon 18a impacts transmitter release and CB1R modulation, with potential implications for cannabinoid-based therapeutics.