# NIH Reporter #1U19AI201306-01

Expression-Based Vaccine

**Recipient:** Johns Hopkins University

**Award Amount:** $352,452.00
**Ceiling:** $352,452.00

**Awarded:** September 17, 2026

**Identifier:** 1U19AI201306-01

NIH-funded research at Johns Hopkins University to develop and evaluate an HCV vaccine using designed antigens to elicit broad antibody and T-cell responses.

### Description

Project to design an expression-based hepatitis C virus vaccine intended to induce broadly neutralizing antibodies and genotype-cross-reactive T-cell responses. The project will map antibody targets, develop and test designed vaccine antigens, and compare immune responses in rhesus macaques and humans with spontaneous HCV clearance.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11451370)