Award
National Institute of Neurological Disorders and Stroke 1R01NS144807-01A1
The novel role of perivascular fibroblasts in secondary injury after cervical SCI
Recipient
Florida International University
Award Amount
$471,698.00
Ceiling
$471,698.00
Awarded
May 14, 2026
Identifier
1R01NS144807-01A1
NIH awarded a grant to Florida International University to study the role of perivascular fibroblasts and PI16 in spinal cord injury, aiming to develop new neuroprotective therapies.
Description
This NIH grant project investigates the role of perivascular fibroblasts in blood-spinal cord barrier dysfunction and secondary injury after spinal cord injury (SCI), focusing on identifying perivascular fibroblast-derived peptidase inhibitor 16 (PI16) as a novel therapeutic target for neuroprotection. The study aims to understand mechanisms regulating fibroblast activation and PI16 upregulation, validate PI16's role in injury outcomes, and assess therapeutic potential of PI16-neutralizing antibody treatment.