Award
National Institute of Allergy and Infectious Diseases 5R01AI109139-07
Using bile salt metabolism to modulate CDI prophylaxis
Recipient
University of Nevada Las Vegas
Award Amount
$715,935.00
Ceiling
$715,935.00
Awarded
August 08, 2025
Identifier
5R01AI109139-07
NIH grant awarded to University of Nevada Las Vegas to develop bile salt analogs for preventing Clostridium difficile infection through modulation of bile salt metabolism.
Description
This project aims to develop a prophylactic approach against Clostridium difficile infection (CDI) by modulating bile salt metabolism. The research focuses on synthesizing and testing heterobicyclic non-hydrolysable bile salts (NHBS) as anti-germinants to prevent CDI. The project builds on five foundational discoveries, including the stability of NHBS in the gut microbiome and their efficacy in protecting mice from CDI.