Award
NIH Reporter #5R01HL170198-03
TMEM16A in human airway disease
Recipient
Washington University, Saint Louis, MO, United States
Award Amount
$623,138.00
Ceiling
$623,138.00
Awarded
April 29, 2026
Identifier
5R01HL170198-03
Research grant awarded to Washington University to study TMEM16A chloride channel and its regulation by CLCA1 in airway diseases, aiming to develop therapies for cystic fibrosis and COPD.
Description
This project investigates the calcium-activated chloride channel TMEM16A and its regulation by CLCA1 protein, aiming to develop therapies for mucus-obstructive diseases such as cystic fibrosis (CF) and COPD. The study involves understanding TMEM16A isoform expression, the impact of CLCA1 on mucus properties, and the structural basis of their interaction, utilizing human CF models, ex vivo tissues, and advanced structural techniques.