Award
NIH Reporter #1R21AI185574-01A1
Adaptation of an in vitro generated human skin model for tick feeding to study Borrelia burgdorferi transmission and colonization
Recipient
University of Nebraska Medical Center
Award Amount
$417,845.00
Ceiling
$417,845.00
Awarded
July 31, 2025
Identifier
1R21AI185574-01A1
Development of a human skin model to study Borrelia burgdorferi transmission by ticks, aiming to reduce animal testing and enable therapeutic screening.
Description
This project adapts and validates a lab-generated human skin model to study the early stages of infection as Borrelia burgdorferi is transmitted from the deer tick into human skin. The model aims to reduce animal use in research and provide insights into skin colonization and dissemination by B. burgdorferi.