Award
NIH Reporter #5F31CA284505-02
The role of mesothelial-derived cancer-associated fibroblasts in the pathogenesis of pancreatic ductal adenocarcinoma
Recipient
University of Michigan at Ann Arbor, Department of Surgery
Award Amount
$47,899.00
Ceiling
$47,899.00
Awarded
August 04, 2025
Identifier
5F31CA284505-02
This award funds research to investigate the role of mesothelial-derived cancer-associated fibroblasts in pancreatic ductal adenocarcinoma, aiming to understand their contribution to the tumor microenvironment and disease progression.
Description
Pancreatic cancer is characterized by the expansion of heterogenous cancer-associated fibroblasts (CAFs) that are believed to play tumor-promoting and tumor-restricting roles in disease progression. This heterogeneity is partly programmed by the diverse cellular origins of CAFs. Preliminary evidence suggests that mesothelial cells give rise to a phenotypically and functionally distinct class of CAFs in pancreatic cancer. The goal of this proposal is to investigate the contribution of mesothelial-derived CAFs to the tumor microenvironment and their functional role in disease progression.