Award
National Institute of Mental Health 5F30MH130078-04
Functional study of the role of SAPAP3 postsynaptic density protein on dorsolateral striatal cholinergic interneurons
Recipient
State University of New York Stony Brook
Award Amount
$54,538.00
Ceiling
$54,538.00
Awarded
August 25, 2025
Identifier
5F30MH130078-04
This award funds research to study the role of SAPAP3 protein in striatal cholinergic interneurons related to OCD, using advanced neuroscience techniques to understand and potentially treat compulsive behaviors.
Description
The project involves electrophysiology, optogenetics, and 2-photon microscopy to study striatal cholinergic interneurons in a mouse model of OCD. The research aims to understand the dysregulation of acetylcholine release and its role in compulsive behaviors. The project focuses on neuropsychiatric disorder research, specifically OCD. It aims to test whether SAPAP3 deletion effects in cholinergic interneurons contribute to OCD-like behaviors and whether targeted therapies could modify these behaviors.