National Institute of Diabetes and Digestive and Kidney Diseases 2P30DK034854-41

Integrated Cell and Microbial Biology of the GI Tract- Core D

Core D supports research on the microbiota's role in health and disease with multiple specialized units and is directed by Lynn Bry MD PhD and Georg Gerber MD PhD.

Description

The Gnotobiotics, Microbiology and Metagenomics Core (Core D), supports investigators studying functional roles of the microbiota in health and disease. Core D has supported >100 groups interested in evaluating mechanisms of action by which the host’s microbiota affects host physiologic and pathophysiologic processes. With a "Focus on Function" Core D aims to advance our understanding of causal effects of the microbiota on host health and disease. Our resources include a Microbiology Unit for microbiologic culturing, phenotyping, analysis of primary samples for microbial metabolite profiles, and the development of defined microbial consortia for functional studies, a Clinical Lab (CLIA) Unit to support microbiome-focused clinical trials, a Molecular Unit for sequence-based analyses, a Gnotobiotic (germfree) mouse facility for in vivo studies in animal models, a Metabolic Unit to support mouse metabolic cage, body composition and metabolism studies, and a Computational Unit which undertakes novel algorithmic development to evaluate longitudinal dynamics of the microbiota and assist users in experimental design for host-microbiota studies. Core D provides support to investigators from multiple academic centers in the greater Boston area. The Core is Directed by Lynn Bry MD PhD and Georg Gerber MD PhD.

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