Award
National Heart, Lung, and Blood Institute 5R01HL170198-03
TMEM16A in human airway disease
Recipient
Washington University
Award Amount
$623,138.00
Ceiling
$623,138.00
Awarded
April 29, 2026
Identifier
5R01HL170198-03
NIH grant awarded to Washington University to study the TMEM16A chloride channel and its regulator CLCA1 in airway diseases, focusing on cystic fibrosis and COPD, with the goal of developing new therapies.
Description
This project investigates the role of the calcium-activated chloride channel TMEM16A and its regulator CLCA1 in human airway diseases such as cystic fibrosis and chronic obstructive pulmonary disease. The study aims to understand TMEM16A isoform expression, evaluate the impact of CLCA1-TMEM16A on mucus properties, and determine the structural basis for CLCA1 potentiation of TMEM16A to develop new therapeutics.