Award
National Institute of Allergy and Infectious Diseases 1R01AI189410-01A1
Macrophage senescence as a driver of granuloma failure and progression to necrosis in TB and TB/HIV
Recipient
Johns Hopkins University
Award Amount
$3,145,850.00
Ceiling
$3,145,850.00
Awarded
September 19, 2025
Identifier
1R01AI189410-01A1
This NIH-funded multiyear award supports research on macrophage senescence in TB and TB/HIV, aiming to understand disease progression and explore new therapies.
Description
The project focuses on the role of macrophage senescence in TB and TB/HIV progression. The award is multiyear, with a total budget of approximately $3.15 million. The project involves spatial transcriptomics and host-directed therapies. The principal investigator is William Ramses BISHAY, and co-investigator is Igor Kramnik. The project is funded by the NIH, specifically the NIAID. The project aims to establish a detailed understanding of senescent macrophages and explore senolytic drugs as potential therapies.