Award
NIH Reporter #1R21EB037871-01A1
Exploiting time-of-flight in photon cascade emissions for direct imaging of therapeutic radionuclides
Recipient
University of Calif-Lawrence Berkeley Lab
Award Amount
$312,165.00
Ceiling
$312,165.00
Awarded
June 02, 2026
Identifier
1R21EB037871-01A1
The award funds the development of a new imaging technology, TOF-MPET, to improve cancer radionuclide therapy imaging by enhancing sensitivity and image quality compared to current methods.
Description
This project aims to develop a novel nuclear imaging modality called time-of-flight multi-photon emission tomography (TOF-MPET) to improve imaging of radiopharmaceutical therapies (RPT) used in cancer treatment. The technology seeks to enhance signal-to-noise ratio and sensitivity compared to existing SPECT imaging, enabling better imaging of alpha therapy radiopharmaceuticals injected at low activities. The project will demonstrate the performance of TOF-MPET with a minimal system, potentially improving cancer diagnosis and treatment monitoring.