Award
National Cancer Institute 5R37CA266727-04
Characterizing cytotoxic therapy induced shifts in the cost-to-benefit ratio of high ploidy
Recipient
H. LEE MOFFITT CANCER CTR & RES INST, TAMPA, FL, UNITED STATES
Award Amount
$562,055.00
Ceiling
$562,055.00
Awarded
August 25, 2025
Identifier
5R37CA266727-04
The award supports research to develop personalized cytotoxic therapy strategies by studying tumor DNA content and metabolic substrates to predict tumor vulnerability, focusing on stomach and brain tumors using advanced sequencing, imaging, and modeling techniques.
Description
This project aims to develop a personalized cytotoxic therapy strategy that considers tumor cell DNA content and dNTP substrate availability to predict tumor vulnerability to increasing SCNA rate, especially in stomach and brain tumors. It involves integrating single-cell sequencing, imaging, and mathematical modeling to understand chromosome missegregations and missegregation tolerances, and evaluating energetic substrates like oxygen, phosphate, and glucose in tumor microenvironments.