Award
NIH Reporter #5R01AR083346-03
Regulation of notochord vacuole biogenesis: investigating its role in spine formation and IVD Biology
Recipient
Duke University, Durham, NC, United States
Award Amount
$506,077.00
Ceiling
$506,077.00
Awarded
December 02, 2025
Identifier
5R01AR083346-03
This NIH-funded research project at Duke University aims to study the mechanisms of notochord vacuole biogenesis and their role in spine formation and intervertebral disc biology, providing insights into spine morphogenesis and related diseases.
Description
The proposed studies will investigate mechanisms regulating notochord vacuole biogenesis and function in zebrafish and mice and will investigate the role of notochord vacuoles in spine formation in mice. These studies will bring important new insights into spine morphogenesis and the origin of pathologies such as congenital scoliosis and disc disease.