National Heart, Lung, and Blood Institute 1R01HL185698-01

Cardiorespiratory and autonomic impacts of coolants in e-cigarette aerosols

NIH awarded a grant to the University of Louisville to study the cardiovascular and respiratory impacts of coolants in e-cigarette aerosols, focusing on their role in increasing nicotine exposure and cardiopulmonary risk, particularly in youth.

Description

This NIH grant project focuses on studying the cardiopulmonary toxicity of coolants used in e-cigarettes, such as menthol, WS-3, and WS-23. The research aims to elucidate how these coolants alter exposure to harmful constituents like nicotine and aldehydes and their effects on cardiovascular and respiratory physiology using murine models. The study will assess acute and chronic effects on cardiac electrophysiology, autonomic tone, ventilatory function, hemodynamics, and toxicant exposure, with attention to age and sex differences. The results will inform regulatory policy and public health strategies to mitigate cardiovascular risk associated with e-cigarette use, especially among youth.

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