Award
National Institute of General Medical Sciences 5R33GM146159-04
Pediatric Sepsis Biorepository and Clinical Database
Recipient
Children's Hospital of Philadelphia
Award Amount
$694,755.00
Ceiling
$694,755.00
Awarded
April 11, 2025
Identifier
5R33GM146159-04
Award for a project to develop a pediatric sepsis biorepository and clinical database, involving biologic data collection and analysis to identify high-risk sepsis phenotypes and guide targeted therapies.
Description
This project aims to test the feasibility of collecting, processing, and analyzing biologic data from blood specimens early in the sepsis course, linking this data to clinical phenotypes from electronic health records (EHR). The study involves deep phenotyping using flow cytometry, proteomics, and bioenergetic evaluations to characterize immune-inflammatory-metabolic responses. The project will expand from a single-center pilot to a multi-site proof-of-concept study to identify biological patterns associated with high-risk sepsis phenotypes, ultimately guiding targeted therapies.