NIH Reporter #1R21EY037547-01

Targeting cholesterol homeostasis for therapy of demyelinating eye disease

Research project funded by NIH NEI to develop therapies targeting cholesterol homeostasis for demyelinating eye diseases, aiming to promote neuroprotection and repair of the optic nerve.

Description

This project aims to explore therapeutic strategies to restore cholesterol homeostasis, promoting neuroprotective and reparative mechanisms, using approaches such as cholesterol redistribution with methyl-beta-cyclodextrins and targeting of the cholesterol sensor TMEM97. The research focuses on understanding and developing therapies for demyelinating eye diseases, which involve immune-mediated damage to the optic nerve and associated structures, leading to vision loss. The project emphasizes the importance of cholesterol regulation in neural health and aims to identify novel therapeutic targets.

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